Tillerson is the CEO of the world's largest oil company.
Mnuchin is Goldman Sachs.
Mattis was an Obama appointee.
Sessions has been in the Senate for decades.
Zinke hasn't been in politics too long, but I can't find anything particularly "anti-establishment" about him.
Ross is a billionaire banker.
Pudzer worked for the Romney campaign.
Price has been in politics for decades.
Carson, I will admit, is an extreme outsider for HUD.
Chao is a life-long Beltway insider.
Perry has done little else than work in politics.
Kelly is an Obama appointee.
DeVos is a billionaire.
Most of these people are anti-establishment in the sense of "your average television news viewer has never heard of them".