It was actually pretty funny back in the 70s and 80s when he took pot shots in similar short books at modern art (The Painted Word--in fact, he's brought up modern art as a subject to be trashed in every book he's written since then) and architecture (From Bauhaus To Our House) because a)he was one of the few people doing it, and b)I didn't feel really very sorry for any of his targets. And dickheaded as he was about it, he made some good points in his "Three Stooges" article (arguing that Norman Mailer, John Updike, and John Irving were writing books about subjects nobody had any reason to care about), and Bonfire Of The Vanities was a good, if utterly unsubtle book.
Now, though he's basically just an old, droolingly square a-hole. The hilarious thing is that although he's a conservative, he's also an atheist. Why if you aren't atheist would you even bother to go after Darwin/evolution...
...it's also occurred to me over the years that he's actually more than anything the father of South Park Republicanism. He didn't really come out as a Republican until after GWB though.