My record-store buddy had a big B-52s phase last year when he bought all their albums, but I can't say I know much beyond "Rock Lobster" and "Love Shack". From what I gather they're the kind of band whose records, once you hear them, compel you to go collect them all. That's not at all a bad thing -- Sparks and the Fall were like that for me -- but I've got a ton of music to get through as it is.
(Hey Billdude: on one of those record-store trips I recommended to him Argybargy, since they had two copies, each for $3, and made a convert -- to that record, at least. I still haven't heard much of their music. "Tempted" is a lot less lame than I remembered it being.)