I took a Simpsons class in university
it was an upper credit elective and I needed an upper credit elective so of course I took the class. The prof was a superfan, but he was also a smart guy and knew that the course had to be legit and not just an excuse to watch tv in class. So he made the assignments and readings really hard to compensate. It was largely a sociology course, lots of Pierre Bourdieu readings and similar folks. Topics like class, gender, family, ageing ect. My final paper was a linguistic analysis of the simpson's use of wordplay. (I got a B-)
Most of the other students in the class didn't know shit about the simpsons btw. Many had never even seen an episode before.
Many people scoff at classes like this, and they're free to do so. But the more time passes and the more cultural touchstones like the Simpsons fall into the past the more they will be kept alive and studied by academics and historians rather than mainstream culture.