Does anybody else here watch "Louie"?
I just finished watching the fifth and final season this week. The trajectory of that show went from less and less funny/quirky to much darker and more depressing around the start of Season 4 or so. I'm not sure how much of that was influenced by problems in his personal life, but it went from a comedy with some dark elements, to the sordid chronicles of a clinically depressive middle-aged man with severe self-loathing issues, with practically no laughs that weren't uncomfortably painful.
And man, that final episode is dark. The last few minutes involve (hope this isn't too spoiler-y) him seeing his hotel-mate crack his skull open and bleed to death in front of him. What a dark note to end his TV series on (there's really no chance of it ever being renewed, I'm assuming).