Sounds like you're understandably playing it pretty safe. Definitely tend to not leave the house most days out of the week myself these days but I do go on short masked 6' away outings with friends now and again and go play my guitar at a park or beach on nice weather weekends. Just helps me stay sane. But the amount of people who go to these public spaces without wearing masks or staying 6' away from others is pretty frustrating to say the least.
I'm sorry to hear that your wife's health is still getting worse, though that's not really surprising given how you described the issues previously. Can't imagine what that must be like and I feel like any words of consolation would just come off as Hallmark "wisdom". Guess I'll just say I'm sorry and that sucks and point out that at least the fact that you're WFH full time (though maybe you were doing that pre-pandemic?) allows you to spend as much time with her as possible.