This information is available on the world wide web. But I'm lonely and unsober, so lemme lend a hand

Three primary components to RPI:

25% your own record (D1)
50% your opponents record (D1)
25% your opponents' opponents' record (D1)

At home, wins are worth 0.7 and losses worth 1.3. On road, wins are worth 1.3 and losses are worth 0.7. Those all get factored into the weightings.

So, if you're asking if it's "significant" from a quantitative perspective, that's a math answer. If you're asking if home and road games are significant in some other way, pray tell more